Overgrowth mods11/9/2022 ![]() ![]() Since BMP7 is important for the maintenance of homeostasis in articular cartilage, we speculate that there is a protective function of LF at the site of joint inflammation.", Taken together, we provide the first evidence to demonstrate that LF activates BMP7 expression through the mitogen-activated protein kinase ERK pathway in primary chondrocytes of articular cartilage. LF-induced increase in BMP7 protein level was in parallel with the phosphorylation of ERK in primary chondrocytes. Interestingly, a specific mitogen-activated protein kinase ERK inhibitor U0126, but not JNK kinase inhibitor SP600125, abrogated LF activation of BMP7 gene expression. We found that LF preferentially activated BMP7 expression rather than BMP2 or BMP4, and that LF activated BMP7 expression in a dose-dependent and time-dependent manner. Effect of LF on gene expression in primary chondrocytes of articular cartilage was investigated in this study. However, the effect of LF on articular cartilage of joints is not well understood. Local concentrations of LF in synovial fluid are much higher in the joints of RA patients. Lactoferrin (LF) is a marker of neutrophil granulocyte activation. Neutrophils release stimulants that alter the chondrocyte metabolism. ![]() Neutrophil granulocytes are the predominant cell type in the synovial fluid of affected joints. Title = "Lactoferrin activates BMP7 gene expression through the mitogen-activated protein kinase ERK pathway in articular cartilage",Ībstract = "Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to destruction of cartilage in joints. Since BMP7 is important for the maintenance of homeostasis in articular cartilage, we speculate that there is a protective function of LF at the site of joint inflammation. ![]() ![]() Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to destruction of cartilage in joints. ![]()
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